The only FDA-approved treatment for patients with Lysosomal Acid Lipase Deficiency (LAL-D)1,2

KANUMA® (sebelipase alfa) is a hydrolytic lysosomal cholesteryl ester and triacylglycerol–specific enzyme indicated for the treatment of patients with a diagnosis of LAL-D.1


KANUMA is administered as an intravenous infusion under the supervision of a healthcare professional.1 For more information, download the full Prescribing Information and Dosing and Administration brochure below:

Download Full Prescribing Information

Download Dosing And Administration Brochure

Getting Started on Kanuma® (sebelipase alfa)

KANUMA is approved by the U.S. Food and Drug Administration as a treatment for patients with a diagnosis of LAL-D.1

Once you have decided that KANUMA is right for your patient, here’s how OneSource™ can help you get your patients with LAL-D started on KANUMA:

Call the OneSource team at 1-888-765-4747 (Monday through Friday, 8:30 am to 8:00 pm [ET]). OneSource Customer Operations will work to facilitate order processing and delivery.

Ask your patient to sign the OneSource enrollment form to start working with a Case Manager.


We’re Here to Help

After your patient signs up, they will be matched with a dedicated Alexion Case Manager who can help answer questions about KANUMA or
LAL-D. OneSource is staffed by Case Managers who provide one-to-one education, assistance with funding options and access to KANUMA, as well as ongoing treatment support for your patients living with LAL-D, and their caregivers.

With our experience and resources, we’re here to help your patient and their caregiver feel supported every step of the way. Here’s an overview of the services we offer.


When your patients or their caregivers have questions about LAL-D or KANUMA, we’ll work to find the answers. Your patient's dedicated Case Manager can provide them with:

  • Educational materials to help your patient learn more about LAL-D
  • Details about KANUMA
  • Information about the treatment process

Health Insurance Navigation

Health insurance can be complicated. We’re here to help make sense of it all. Your patient's Case Manager can help by:

  • Providing information that explains your patient’s insurance coverage for KANUMA
  • Addressing financial concerns or gaps in coverage
  • Informing your patient of infusion centers or other treatment location options nearby

Community Connections

With OneSource by your patient’s side, they’ll never have to go through it alone. Connect with others in the rare disease community who understand your patient’s experience. We can share information about: 

  • In-person and online meetings and events specific to your patient’s condition
  • Support and resources
  • Advocacy groups
  • A peer-to-peer program called Peer Connects

Ongoing Support

When life takes a turn, OneSource is ready to keep your patient on track. Your patient's Case Manager is ready to help:

  • Guide your patient through insurance changes or finding new treatment locations
  • Navigate your patient's treatment through life events, such as getting married, starting a new job, moving, or traveling
  • Work with you and the patient's specialty pharmacy to ensure your patient keeps receiving their medicine as prescribed

Co Pay Program

Here are some additional services we provide to help support your patient with KANUMA

Financial Assistance

We can provide information about resources available that may be able to help cover the costs for KANUMA.

If your patient has Medicare, Medicaid, or another federal- or state-funded insurance plan, we can connect them to third-party resources that may be able to help with financial assistance.

If your patient has commercial insurance, they may be eligible for the Alexion OneSource CoPay Program, which may be able to help cover some
out-of-pocket treatment costs.

To be eligible for the CoPay Program, your patient must:

  • Be signed up for patient services through OneSource
  • Have commercial insurance (not part of a federal- or state-funded healthcare program)
  • Be prescribed KANUMA for an FDA-approved indication
  • Reside in the United States or its territories


Help get your patient connected

with their OneSource

Case Manager


Monday through Friday,

8:30 AM to 8:00 PM (ET) or visit the website at

Connect with Alexion:     Medical Information